M. Tohyama et al., ANEURYSMAL DILATATION OF DUCTUS-ARTERIOSUS DURING LIPO-PROSTAGLANDIN-E(1) THERAPY FOR DIAPHRAGMATIC-HERNIA, European journal of pediatrics, 152(11), 1993, pp. 877-879
We report a case of congenital diaphragmatic hernia in which aneurysma
l dilatation of ductus arteriosus developed after lipo-prostaglandin E
1 (PGE1) therapy for persistent fetal circulation. After surgery Lipo-
PGE1 was used at a dosage of 5 ng/kg per minute from days 2-9 during w
hich aneurysmal dilatation (7 mm in diameter) developed and remained t
hereafter. Ductus arteriosus ligation was then performed. Lipo-PGE1 ma
y promote ductus arteriosus dilatation in cases of persistent fetal ci
rculation.