EFFECTS OF ALPRAZOLAM ON CELLULAR IMMUNE-RESPONSE TO SURGICAL STRESS IN MICE

Authors
FREIREGARABAL M NUNEZ MJ BALBOA JL FERNANDEZRIAL JC VALLEJO LG GONZALEZBAHILLO J REYMENDEZ M
Citation
M. Freiregarabal et al., EFFECTS OF ALPRAZOLAM ON CELLULAR IMMUNE-RESPONSE TO SURGICAL STRESS IN MICE, Cancer letters, 73(2-3), 1993, pp. 155-160
Citations number
36
Categorie Soggetti
Oncology
Journal title
Cancer letters → ACNP
ISSN journal
03043835
Volume
73
Issue
2-3
Year of publication
1993
Pages
155 - 160
Database
ISI
SICI code
0304-3835(1993)73:2-3<155:EOAOCI>2.0.ZU;2-J
Abstract
Mice exposed to surgical stress induced by laparotomy and treated with chronic alprazolam (0.5-2 mg/kg) showed a dose-dependent reduction in stress-induced suppression of the natural killer (NK) cell activity. These immunoenhancing effects of alprazolam were more intense when it administered before the surgery was performed.