FLUID SHIFTS INDUCED BY THE ADMINISTRATION OF 7.5-PERCENT SODIUM-CHLORIDE IN 6-PERCENT DEXTRAN-70 (HSD) IN DEHYDRATED SWINE

This study determined the effects of HSD administration on fluid distr ibution, following dehydration in Female Yucatan micro pigs. Dehydrati on at 33-degrees-C resulted in: significantly increased core temperatu re (37.2 +/- 0.2 (mean +/- SE) to 39.0 +/- 0.1-degrees-C), and decreas ed (4.4 +/- 0.4%) body weight and plasma volume (PV, 43 +/- 2 to 37 +/ - 1 ml/kg). HSD but not saline administration resulted in significant increases (over postdehydration levels) in PV (46 +/- 3 ml/kg), sodium concentration (141 +/- 1 to 150 +/- 2 mEq/L), and osmolality (291 +/- 2 to 307 +/- 11 mOsm). Followintg return of water to the animals, the se values returned to baseline levels. Since insensible (respiratory a nd transdermal) water loss for the 24 hr at 23-degrees-C was 714 +/- 6 4 ml, and for the 24 hr at 33-degrees-C was 653 +/- 64 ml, increasing the ambient temperature did not result in increased dehydration in swi ne. HSD administration restored PV to baseline levels despite prior wa ter loss dehydration. (C) 1993 Wiley-Liss, Inc.