Yz. Patt et al., LOW SERUM ALPHA-FETOPROTEIN LEVEL IN PATIENTS WITH HEPATOCELLULAR-CARCINOMA AS A PREDICTOR OF RESPONSE TO 5-FU AND INTERFERON-ALPHA-2B, Cancer, 72(9), 1993, pp. 2574-2582
Background. A Phase II clinical trial was conducted to evaluate the ef
ficacy of intravenous fluorouracil (5-FU) and subcutaneous recombinant
interferon-alpha-2b (rIFN-alpha-2b) in the treatment of hepatocellula
r carcinoma (HCC) and to define factors that might be predictive of a
response to treatment. Methods. Twenty-nine patients were registered o
n the protocol. 5-FU was administered as a continuous intravenous (IV)
infusion (dose = 750 mg/m2) for 5 consecutive days. rIFN-alpha-2b was
administered subcutaneously (SC) (dose 5 x 10(6) mum/m2) once a day o
n days 1, 3, and 5 of the 5-FU infusion. The treatment was repeated at
14-day intervals. Responses were assessed at the end of one course of
therapy, which was equivalent to four treatments. Results. Of the 28
patients evaluable for response, 5 (18%) had a partial response, and 1
(4%) had a minor response. Responses lasted from more than 2 to more
than 24 months (median, 11.5 months). Ten (36%) patients experienced n
o response, and 12 (43%) had progressive disease. The 6 responders wer
e part of a group of 16 patients who had pretreatment levels of serum
alpha-fetoprotein (AFP) of 50 ng/ml or less and a group of 8 whose tum
ors involved 50% or less of the liver parenchyma. Mucositis, which occ
urred in 54% of the patients, was the most common toxicity associated
with the treatment regimen. Diarrhea and dermatitis were observed in 1
6% and 17% of the patients, respectively; fatigue, thrombocytopenia, g
ranulocytopenia, neurologic toxicity, and nausea and vomiting were not
commonly seen. Conclusions. The regimen of IV 5-FU and SC rIFN-alpha-
2b was well tolerated and induced durable partial response in 31% (5 o
f 16) of patients with HCC who had low levels of serum AFP and in thos
e with 50% or less of liver replacement. In contrast, the treatment re
gimen was ineffective in patients with HCC who had high levels of seru
m AFP or extensive liver disease.