LOW SERUM ALPHA-FETOPROTEIN LEVEL IN PATIENTS WITH HEPATOCELLULAR-CARCINOMA AS A PREDICTOR OF RESPONSE TO 5-FU AND INTERFERON-ALPHA-2B

Citation
Yz. Patt et al., LOW SERUM ALPHA-FETOPROTEIN LEVEL IN PATIENTS WITH HEPATOCELLULAR-CARCINOMA AS A PREDICTOR OF RESPONSE TO 5-FU AND INTERFERON-ALPHA-2B, Cancer, 72(9), 1993, pp. 2574-2582
Citations number
35
Categorie Soggetti
Oncology
Journal title
CancerACNP
ISSN journal
0008543X
Volume
72
Issue
9
Year of publication
1993
Pages
2574 - 2582
Database
ISI
SICI code
0008-543X(1993)72:9<2574:LSALIP>2.0.ZU;2-S
Abstract
Background. A Phase II clinical trial was conducted to evaluate the ef ficacy of intravenous fluorouracil (5-FU) and subcutaneous recombinant interferon-alpha-2b (rIFN-alpha-2b) in the treatment of hepatocellula r carcinoma (HCC) and to define factors that might be predictive of a response to treatment. Methods. Twenty-nine patients were registered o n the protocol. 5-FU was administered as a continuous intravenous (IV) infusion (dose = 750 mg/m2) for 5 consecutive days. rIFN-alpha-2b was administered subcutaneously (SC) (dose 5 x 10(6) mum/m2) once a day o n days 1, 3, and 5 of the 5-FU infusion. The treatment was repeated at 14-day intervals. Responses were assessed at the end of one course of therapy, which was equivalent to four treatments. Results. Of the 28 patients evaluable for response, 5 (18%) had a partial response, and 1 (4%) had a minor response. Responses lasted from more than 2 to more than 24 months (median, 11.5 months). Ten (36%) patients experienced n o response, and 12 (43%) had progressive disease. The 6 responders wer e part of a group of 16 patients who had pretreatment levels of serum alpha-fetoprotein (AFP) of 50 ng/ml or less and a group of 8 whose tum ors involved 50% or less of the liver parenchyma. Mucositis, which occ urred in 54% of the patients, was the most common toxicity associated with the treatment regimen. Diarrhea and dermatitis were observed in 1 6% and 17% of the patients, respectively; fatigue, thrombocytopenia, g ranulocytopenia, neurologic toxicity, and nausea and vomiting were not commonly seen. Conclusions. The regimen of IV 5-FU and SC rIFN-alpha- 2b was well tolerated and induced durable partial response in 31% (5 o f 16) of patients with HCC who had low levels of serum AFP and in thos e with 50% or less of liver replacement. In contrast, the treatment re gimen was ineffective in patients with HCC who had high levels of seru m AFP or extensive liver disease.