GENERATION AND PROPAGATION OF ECTOPIC BEATS INDUCED BY SPATIALLY LOCALIZED NA-K PUMP INHIBITION IN ATRIAL NETWORK MODELS

Authors
WINSLOW RL VARGHESE A NOBLE D ADLAKHA C HOYTHYA A
Citation
Rl. Winslow et al., GENERATION AND PROPAGATION OF ECTOPIC BEATS INDUCED BY SPATIALLY LOCALIZED NA-K PUMP INHIBITION IN ATRIAL NETWORK MODELS, Proceedings - Royal Society. Biological Sciences, 254(1339), 1993, pp. 55-61
Citations number
22
Categorie Soggetti
Biology
Journal title
Proceedings - Royal Society. Biological Sciences → ACNP
ISSN journal
09628452
Volume
254
Issue
1339
Year of publication
1993
Pages
55 - 61
Database
ISI
SICI code
0962-8452(1993)254:1339<55:GAPOEB>2.0.ZU;2-P
Abstract
A biophysically detailed two-dimensional network model of the cardiac atrium has been implemented on the Thinking Machines massively paralle l CM-5 supercomputer. The model is used to study the effects of spatia lly localized inhibition of the Na-K pump. Na overloading produced by pump inhibition can induce spontaneous, propagating ectopic beats with in the network. At a cell-to-cell coupling value yielding a realistic plane wave conduction velocity of 0.6 m s(-1), pump inhibition in roug hly 1000 cells can induce propagating ectopic beats in a 512 x 512 lat tice of cells.