PROGNOSTIC FACTORS FOLLOWING ENUCLEATION OF 111 UVEAL MELANOMAS

Citation
K. Coleman et al., PROGNOSTIC FACTORS FOLLOWING ENUCLEATION OF 111 UVEAL MELANOMAS, British journal of ophthalmology, 77(11), 1993, pp. 688-692
Citations number
28
Categorie Soggetti
Ophthalmology
ISSN journal
00071161
Volume
77
Issue
11
Year of publication
1993
Pages
688 - 692
Database
ISI
SICI code
0007-1161(1993)77:11<688:PFFEO1>2.0.ZU;2-1
Abstract
Follow up information was retrieved on III patients who underwent enuc leation for uveal melanoma between 1964 and 1987, allowing a minimum p ostoperative period of 5 years. Univariate survival analysis was carri ed out using Kaplan-Meier curves and the differences between the curve s were analysed with the Mantel-Cox test. Multivariate analysis used t he Cox proportional hazards model. Univariate analysis isolated each o f the following as significant prognosticators: largest tumour diamete r (LTD) (p<0.002), presence of epithelioid cells (p<0.03), and glaucom a (p<0.001). A combination of cell type, glaucoma, and LTD (p<0.0001) had strong and independent prognostic significance in multivariate ana lysis. The results of this series are compared with previous studies a nd the value of cell type information and new quantitative parameters is discussed.