J. Zawadzki et al., HYPOURICEMIA DUE TO INCREASED TUBULAR SECRETION OF URATE IN CHILDREN WITH AMANITA-PHALLOIDES POISONING, Nephron, 65(3), 1993, pp. 375-380
The tubular transport of urate was studied in 20 children poisoned wit
h Amanita phalloides and in control group. The aim of this study was t
o investigate the cause of repeatedly observed episodes of hypouricemi
a in patients after A. phalloides poisoning. A significant negative co
rrelation between serum uric acid concentration and fractional excreti
on of urate in poisoned and control groups (r = 0.73, p<0.001) was fou
nd. The results of pyrazinamide and probenecid tests performed in pati
ents after A. phalloides poisoning indicated that hyperuricosuria was
most likely due to an increment in renal tubular urate secretion, and
not due to decreased presecretory and postsecretory reabsorption of ur
ic acid. These findings indicate that hypouricemia found after A. phal
loides poisoning in children is of renal origin due to an increase in
tubular urate secretion.