HYPOURICEMIA DUE TO INCREASED TUBULAR SECRETION OF URATE IN CHILDREN WITH AMANITA-PHALLOIDES POISONING

The tubular transport of urate was studied in 20 children poisoned wit h Amanita phalloides and in control group. The aim of this study was t o investigate the cause of repeatedly observed episodes of hypouricemi a in patients after A. phalloides poisoning. A significant negative co rrelation between serum uric acid concentration and fractional excreti on of urate in poisoned and control groups (r = 0.73, p<0.001) was fou nd. The results of pyrazinamide and probenecid tests performed in pati ents after A. phalloides poisoning indicated that hyperuricosuria was most likely due to an increment in renal tubular urate secretion, and not due to decreased presecretory and postsecretory reabsorption of ur ic acid. These findings indicate that hypouricemia found after A. phal loides poisoning in children is of renal origin due to an increase in tubular urate secretion.