Hypercalciuria and nephrocalcinosis are not uncommon in patients with
Wilson's disease but have only once been reported as the presenting si
gn. We diagnosed Wilson's disease in a 17-year-old male patient 6 year
s after his first episode of gross hematuria and 2 years after detecti
on of hypercalciuria and nephrocalcinosis. Therapy with penicillamine
resulted only in a moderate reduction of urinary calcium excretion but
oxalate excretion increased.