ROLE OF NEW ANTIOXIDANTS IN THE STABILIZATION OF OPHTHALMIC AND EAR DOSAGE FORM PREPARATION OF HAMYCIN

The study involves the development of eye-ointment and ear-drop dosage form of hamycin, a polyene antifungal antibiotic, using anti-oxidants and stabilisers to enhance the stability of these dosage forms. It ha s been found that incorporation of hydroquinone (HQ), butylated hydrox y anisole (BHA), nordihydroguiaretic acid (NDGA), sodium deoxycholate (DSC) and ascorbyl palmitate (AP) in varying combinati6ns in the dosag e preparation have enhanced the stability and preserved physicochemica l properties of the ointment for a period of 12 months period under re frigerated temperature (8+2(0)C) conditions. It was further observed t hat this dosage preparation is more stable in polyethylene glycol base s than in lanolin bases. Ear-drops dosage preparation has shown stabil ity for 12 months period in the presence of BHA and in combination of other antioxidants under refrigerated temperature. However, ear-drops dosage form was found to be stable only for a period of 6 months in am bient condition. It is therefore, recommended that these dosage prepar ations be stored in refrigerated conditions.