Ad. Maxson et al., USE OF A BOVINE HEMOGLOBIN PREPARATION IN THE TREATMENT OF CYCLIC OVARIAN HEMORRHAGE IN A MINIATURE HORSE, Journal of the American Veterinary Medical Association, 203(9), 1993, pp. 1308-1311
Anemia that was secondary to ovarian hemorrhage in a 4-year-old miniat
ure horse mare was treated prior to laparotomy with polymerized ultrap
urified bovine hemoglobin (PUBH). Two previous whole-blood transfusion
s had resulted in acute transfusion reaction, and a suitable blood don
or could not be found among 9 horses, necessitating use of the blood s
ubstitute. Subsequent blood typing revealed the mare to be Aa-negative
, with allo-antibodies against Aa in serum. Serious adverse reactions
were not observed after infusion of PUBH, and the mare recovered. Alth
ough the safety and efficacy of using PUBH in horses has not been esta
blished, PUBH may prove to be an excellent alternative to whole-blood
transfusions, when indicated.