LOCOREGIONAL IMMUNOTHERAPY OF HEAD AND NECK CANCERS UTILIZING ALLOGENEIC SPLEEN-CELLS - A REPORT OF 2 CASES

Authors
KUBOTA E KATANO M IMAMURA H KUROKAWA H KATSUKI T YAMAMOTO H HISATSUGU T NAGUMO F TADANO J
Citation
E. Kubota et al., LOCOREGIONAL IMMUNOTHERAPY OF HEAD AND NECK CANCERS UTILIZING ALLOGENEIC SPLEEN-CELLS - A REPORT OF 2 CASES, Biotherapy, 6(3), 1993, pp. 175-182
Citations number
23
Categorie Soggetti
Medicine, Research & Experimental",Biology
Journal title
Biotherapy → ACNP
ISSN journal
0921299X
Volume
6
Issue
3
Year of publication
1993
Pages
175 - 182
Database
ISI
SICI code
0921-299X(1993)6:3<175:LIOHAN>2.0.ZU;2-E
Abstract
Frozen-stored human spleen cells (SC) cultured with streptococcus prep aration OK-432 acquired direct cytotoxicity to autologous as well as a llogeneic tumor cells. The activated cells started to produce cytocida l cytokine TGIF, which is distinct from previously known cytokines. We examined the possibility of allogeneic adoptive immunotherapy (AIT) u sing these OK-432-stimulated spleen cells (OK-SC) in two cancer patien ts. Rapid necrosis of cancer tissue and remarkable decreases of tumor markers in tumor effusion were observed. There were no severe side eff ects.