K. Takahashi et al., PERCUTANEOUS PERMEATION OF BASIC COMPOUNDS THROUGH SHED SNAKE SKIN ASA MODEL MEMBRANE, Journal of Pharmacy and Pharmacology, 45(10), 1993, pp. 882-886
Relationships between the in-vitro permeability of basic compounds thr
ough shed snake skin as a suitable model membrane for human stratum co
rneum and their physicochemical properties were investigated. Compound
s with low pK(a) values were selected to compare the permeabilities of
non-ionized forms of the compounds. Steady-state penetration was achi
eved immediately without a lag time for all compounds. Flux rate and p
ermeability coefficient were calculated from the steady-state penetrat
ion data and relationships between these parameters and the physicoche
mical properties were investigated. The results showed that permeabili
ty may be controlled by the lipophilicity and the molecular size of th
e compounds. Equations were developed to predict the permeability from
the molecular weights and the partition coefficients of basic compoun
ds.