SEQUESTRATION PATTERN OF PARASITIZED ERYTHROCYTES IN CEREBRUM, MID-BRAIN, AND CEREBELLUM OF PLASMODIUM-COATNEYI-INFECTED RHESUS-MONKEYS (MACACA-MULATTA)

Six rhesus monkeys (Macaca mulatta) infected with Plasmodium coatneyi were studied for parasitized red blood cell (PRBC) sequestration in mi crovessels of the brain. The degree of PRBC sequestration is different in the cerebral, mid-brain, and cerebellar microvessels, with sequest ration occurring preferentially in the cerebellum. This pattern resemb les that of PRBC sequestration in cerebral and cerebellar microvessels in human falciparum malaria. The morphologic appearance of sequestere d cells under light and electron microscopy as well as the PRBC seques tration pattern bolsters the contention that the rhesus monkey infecte d with P. coatneyi is an appropriate primate model for the experimenta l study of human cerebral malaria.