FRONTAL-LOBE METABOLISM AND CEREBRAL MORPHOLOGY IN SCHIZOPHRENIA - P-31 MRS AND MRI STUDIES

Authors
KESHAVAN MS SANDERS RD PETTEGREW JW DOMBROWSKY SM PANCHALINGAM KS
Citation
Ms. Keshavan et al., FRONTAL-LOBE METABOLISM AND CEREBRAL MORPHOLOGY IN SCHIZOPHRENIA - P-31 MRS AND MRI STUDIES, Schizophrenia research, 10(3), 1993, pp. 241-246
Citations number
36
Categorie Soggetti
Psychiatry,"Clinical Neurology
Journal title
Schizophrenia research → ACNP
ISSN journal
09209964
Volume
10
Issue
3
Year of publication
1993
Pages
241 - 246
Database
ISI
SICI code
0920-9964(1993)10:3<241:FMACMI>2.0.ZU;2-4
Abstract
The relation between frontal lobe membrane phospholipid metabolism as measured by 31Phosphorus magnetic resonance spectroscopy (P-31 MRS) an d cerebral morphology as measured on magnetic resonance images (MRI) w as examined in nine first episode neuroleptic naive schizophrenic pati ents. Total corpus callosal area was significantly correlated with pho sphodiester concentration. When examined separately, this relation was confined to the rostral quartile (genu) of the corpus callosum. The p athophysiological significance of this finding is discussed in relatio n to neurodevelopmental hypotheses of schizophrenia.