Ib. Koul et A. Kapil, EVALUATION OF THE LIVER PROTECTIVE POTENTIAL OF PIPERINE, AN ACTIVE PRINCIPLE OF BLACK AND LONG PEPPERS, Planta medica, 59(5), 1993, pp. 413-417
Piperine, an active alkaloidal constituent of the extract obtained fro
m Piper longum and Piper nigrum, was evaluated for its antihepatotoxic
potential in order to validate its use in traditional therapeutic for
mulations. This plant principle exerted a significant protection again
st tert-butyl hydroperoxide and carbon tetrachloride hepatotoxicity by
reducing both in vitro and in vivo lipid peroxidation, enzymatic leak
age of GPT and AP, and by preventing the depletion of GSH and total th
iols in the intoxicated mice. Silymarin, a known hepatoprotective drug
was tested simultaneously for comparison. Piperine showed a lower hep
atoprotective potency than silymarin.