ENHANCEMENT OF PHYTOHEMAGGLUTININ-INDUCED LYMPHOPROLIFERATIVE RESPONSE BY INDOMETHACIN, THYMEX-L OR THEIR COMBINATION IN LUNG-CANCER PATIENTS

Several studies showed that thymic factors and prostaglandin synthesis inhibitors enhance in vitro lymphoproliferative response (LPR) to mit ogens in cancer patients. in this study we investigated whether indome thacin and thymic extract (Thymex L), applied in combination, may in a synergistic pattern influence phytohemagglutinin-induced LPR in lung cancer patients. The results demonstrate that the use of the investiga ted agents enhances LPR to a similar level in hyporeactive patients be fore, as well as after, therapy. However, this drug combination exerts an additive effect on LPR, but only in patients who underwent cytored uctive radiation therapy, indicating the potential usefulness of this drug combination as an adjuvant treatment of these patients.