A secular trend towards higher final height and earlier pubertal matur
ation is seen in countries with favourable socio-economic development
and higher social classes in countries are also associated with taller
height and earlier maturation. Environmental factors, such as nutriti
on and infections, appear to be the main causes for differences in gro
wth and maturation between ethnic and social groups. Differences in fi
nal height are mainly due to prepubertal growth. Studies on immigrant
children and children adopted into privileged conditions from developi
ng countries confirm the influence of early growth on subsequent growt
h. Catch-up growth in adopted children could only partially compensate
for early stunting, and in several cases was cut short by early puber
tal development. A minority developed very early puberty and eventuall
y very short final height. The optimal rate of catch-up growth, the tr
igger mechanism for early puberty, and the effect of various types of
nutritional intervention need to be studied. The studies reported here
indicate the critical importance of optimal intra-uterine, infant and
childhood growth as a basis for satisfactory growth during adolescenc
e.