Jl. Alio et al., TREATMENT OF EXPERIMENTAL ACUTE CORNEAL INFLAMMATION WITH INHIBITORS OF THE OXIDATIVE-METABOLISM, Ophthalmic research, 25(5), 1993, pp. 331-336
The authors studied the effect of topical 2% 6-aminonicotinamide and 0
.1 % adenosine on an experimental model of acute corneal inflammation.
Luminol-enhanced chemiluminescence (LAC), as an indirect measurement
of free-radical release, and computer-assisted planimetry of the corne
al ulcer and its infiltrate were performed both ex vivo and in vivo on
the fifth day following the induction of experimental alkali burn ker
atitis. The authors proved that both drugs significantly inhibited LAC
both ex vivo and in vivo and that such treatments had also a signific
ant beneficial effect on the evolution of the corneal ulcer and its in
filtrate. To the best of the authors' knowledge, this finding had not
been previously reported in experimental corneal inflammation and may
indicate that treatment with inhibitors of the oxidative metabolism co
uld offer a new approach in the pharmacological modulation of acute co
rneal inflammation.