NEW PLATINUM(II) COMPLEXES OF BETA-CYCLODEXTRIN DIAMINE DERIVATIVES AND THEIR ANTITUMOR-ACTIVITY

Authors
CUCINOTTA V MANGANO A NOBILE G SANTORO AM VECCHIO G
Citation
V. Cucinotta et al., NEW PLATINUM(II) COMPLEXES OF BETA-CYCLODEXTRIN DIAMINE DERIVATIVES AND THEIR ANTITUMOR-ACTIVITY, Journal of inorganic biochemistry, 52(3), 1993, pp. 183-190
Citations number
17
Categorie Soggetti
Biology,"Chemistry Inorganic & Nuclear
Journal title
Journal of inorganic biochemistry → ACNP
ISSN journal
01620134
Volume
52
Issue
3
Year of publication
1993
Pages
183 - 190
Database
ISI
SICI code
0162-0134(1993)52:3<183:NPCOBD>2.0.ZU;2-6
Abstract
The new platinum(II) complexes of beta-cyclodextrin functionalized at the primary position with ethylenediamine or with propylenediamine wer e synthesized and characterized by mass spectrometry, electronic spect rophotometry, and multinuclear NMR spectroscopy. Platinum(II) complexa tion makes the cavity more asymmetric. These complexes were tested in vitro for their cytotoxic activity. The relevance of the low activity observed regarding the interaction between the cell and the cyclodextr in cavity is discussed.