Lg. Romanova et al., A GENETIC, PHYSIOLOGICAL, AND BIOCHEMICAL INVESTIGATION OF AUDIOGENIC-SEIZURES IN RATS, Behavior genetics, 23(5), 1993, pp. 483-489
Two kinds of audiogenic seizures are characteristic of the KM rat stra
in, selected by Krushinsky and Molodkina in Moscow in the 1940s. This
strain is now approximately 100% sound sensitive. Diallel crosses have
demonstrated the polygenic nature of this behavior, with most alleles
for seizures being recessive. Myoclonic seizures which develop after
several sound exposures are a special form of kindling, involving the
limbic system. Selection for low and high rates of myoclonic seizures
was successful. Several unique, physiological features of the audiogen
ic seizures in this rat strain are described, as well as data on RNA a
nd protein synthesis inhibition effects on seizure formation.