FLUCONAZOL PLUS OFLOXACIN IN PROPHYLAXIS OF INFECTIONS IN PATIENTS WITH ACUTE-LEUKEMIA - A COMPARATIVE-STUDY

In a retrospective study the incidence of infections, number of afebri le days, duration of antimicrobial chemotherapy, and cost of antibacte rials and antimycotics were compared in two groups of patients. One wa s a group of 57 patients who received no prophylaxis during induction remission therapy of acute leukemia treated in 1989-1990, the second w as a group of 22 patients treated in 1991 where prophylaxis with fluco nazol and ofloxacin was administered. For ethical reasons pertaining s ince 1991, when prophylaxis became mandatory, the study was not random ized. A decrease in the number of febrile days, the cost of antimicrob ials and the duration of treatment with antibiotics and antimycotics w as observed in the group receiving fluconazol and ofloxacin.