FEMORAL HYPOPLASIA - UNUSUAL FACIES SYNDROME - PRENATAL ULTRASONOGRAPHIC OBSERVATIONS

FH-UFS is a rare syndrome characterized by bilateral femoral hypoplasi a, together with facial dysmorphism. To the best of our knowledge, thi s is the first report describing prenatal ultrasonographic findings an d in utero growth pattern of an infant with FH-UFS. Via analysis of ou r data it appears that the growth of the femur in our case was normal until the 24th week of pregnancy, at which time some in-utero insult o ccurred, resulting in temporarily arrested femoral growth. From the 34 th week of pregnancy onward femoral growth rates returned to normal. W e assume, therefore, that the etiology of FH-UFS is multifactorial. On ly a combination of some hereditary proclivity, together with an intra uterine insult (possibly viral) could explain the appearance in the sa me fetus of cleft palate, developing at the 7th week of gestation, and a time-specific (25-32 weeks) disturbance of femoral growth.