SYNTHESIS AND LOCAL-ANESTHETIC ACTIVITY OF ALKYLAMINOACYL DERIVATIVESOF 2-AMINO-1,3,4-THIADIAZOLE

Authors
MAZZONE G PIGNATELLO R MAZZONE S PANICO A PENNISI G CASTANA R MAZZONE P
Citation
G. Mazzone et al., SYNTHESIS AND LOCAL-ANESTHETIC ACTIVITY OF ALKYLAMINOACYL DERIVATIVESOF 2-AMINO-1,3,4-THIADIAZOLE, Il Farmaco, 48(9), 1993, pp. 1207-1224
Citations number
13
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
48
Issue
9
Year of publication
1993
Pages
1207 - 1224
Database
ISI
SICI code
0014-827X(1993)48:9<1207:SALAOA>2.0.ZU;2-Y
Abstract
We prepared some series of 2-(alkylaminoacyl) derivatives of 2-amino-1 ,3,4-thiadiazoles. Most terms were subjected to a biological screening showing a local anesthetic activity both in infiltration and trunkula r tests. For some of the assayed derivatives, the activity was compara ble to that of lidocaine, taken as the reference molecule. From the ob tained results an acceptable relationship between some structural feat ures and activity was drawn.