SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF OYL-6-BETA-THIENYL-4,5-DIHYDROPYRIDAZIN-3-(2H)ONES

Authors
PINNA GA CURZU MM GAVINI E MULE A PIRISINO G SATTA M PEANA A
Citation
Ga. Pinna et al., SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF OYL-6-BETA-THIENYL-4,5-DIHYDROPYRIDAZIN-3-(2H)ONES, Il Farmaco, 48(9), 1993, pp. 1239-1248
Citations number
8
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
48
Issue
9
Year of publication
1993
Pages
1239 - 1248
Database
ISI
SICI code
0014-827X(1993)48:9<1239:SAPAOO>2.0.ZU;2-E
Abstract
A new series of oyl-6-beta-thienyl-4,5-dihydropyridazin-3-(2H)ones 4a- g have been synthesized and tested for their anti-inflammatory and ana lgesic properties. Among the tested compounds, only 4f at 1 mmole/Kg s howed antiinflammatory activity that was comparable with that of indom ethacin (5 mg/Kg) though of shorter duration. Compounds 4a, 4e and esp ecially 4g at 0.2 mmoles/Kg displayed relevant analgesic activity, 4g being the most potent derivative in the writhing test. Compounds 4c an d 4g were found to possess analgesic activity also in the hot plate te st.