SYNTHESIS AND EVALUATION OF GASTROPROTECTIVE ACTIVITY OF OMEPRAZOLE RELATED BENZIMIDAZOLE, IMIDAZO[4,5-B]PYRIDINE AND QUINOXALINE 2-SUBSTITUTED DERIVATIVES

Twenty compounds possessing benzimidazole, imidazo[4,5-b]pyridine and quinoxaline structure bearing either a substituted arylmethylmercapto- or an arylmethylsulfinyl group in position 2 were prepared in order t o evaluate an antiulcer and gastroprotective activity in rat pylorus l igature, in comparison with omeprazole at the dose of 50 mg/kg after i .m. administration. One third of these compounds showed a moderate act ivity, being about half potent as omeprazole.