PYRROLO[1',2' 1,2]IMIDAZO[4,5-B]PYRIDINES, PYRROLO-[2',1' 2,3]IMIDAZO[4,5-C]PYRIDINES AND PYRROLO[2,1-F]PURINES AS POTENTIAL BENZODIAZEPINELIGANDS

Authors
CHIMIRRI A GRASSO S MONFORTE P ZAPPALA M GENCHI G
Citation
A. Chimirri et al., PYRROLO[1',2' 1,2]IMIDAZO[4,5-B]PYRIDINES, PYRROLO-[2',1' 2,3]IMIDAZO[4,5-C]PYRIDINES AND PYRROLO[2,1-F]PURINES AS POTENTIAL BENZODIAZEPINELIGANDS, Il Farmaco, 48(9), 1993, pp. 1261-1269
Citations number
13
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
48
Issue
9
Year of publication
1993
Pages
1261 - 1269
Database
ISI
SICI code
0014-827X(1993)48:9<1261:P1P2>2.0.ZU;2-F
Abstract
The synthesis of some 6H-pyrrolo[1',2':1,2]imidazo[4,5-b]pyridin-6-one s, 5,5a,6,7-tetrahydro-8H-pyrrolo [2',1':2,3]imidazo[4,5-c]pyridin-8-o nes and 7,8,8a,9-tetrahydro-6H-pyrrolo[2,1-f]purin-6-ones is reported. The structure of the obtained compounds has been assigned by means of H-1-NMR spectra assisted by NOESY measurements. In addition, the abil ity to displace [H-3]-flunitrazepam binding from rat brain membranes i s determined. Only the pyrrolopurine derivative 5d binds to the benzod iazepine receptor (BZR) with appreciable potency.