SYNTHESIS AND A(1)-ADENOSINE RECEPTORS AFFINITIES OF PURINO[7,8-C]QUINAZOLINE-8,10(9H,11H)-DIONES AS RIGID ANALOGS OF 8-ARYLXANTHINES

Authors
CECCARELLI S DALESSANDRO A MAGNANTE F SCURI R ZANARELLA S
Citation
S. Ceccarelli et al., SYNTHESIS AND A(1)-ADENOSINE RECEPTORS AFFINITIES OF PURINO[7,8-C]QUINAZOLINE-8,10(9H,11H)-DIONES AS RIGID ANALOGS OF 8-ARYLXANTHINES, Il Farmaco, 48(9), 1993, pp. 1301-1312
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
48
Issue
9
Year of publication
1993
Pages
1301 - 1312
Database
ISI
SICI code
0014-827X(1993)48:9<1301:SAARAO>2.0.ZU;2-8
Abstract
Title compounds were prepared by a cyclocondensation reaction between 8-(2-aminophenyl)xanthines and trialkyl orthoesters. Some of them show ed activities as A1-adenosine receptor antagonists with binding values in the micromolar range. Results are discussed with reference to 1,3- dialkyl-8-arylxanthines. Considerations on the role played by both ele ctronic and conformational factors are also reported.