AN EVALUATION OF HOFMANN AND COPE ELIMINATION ROUTES TO (PLUS-OR-MINUS)-2-N-PROPYLTHIETANE

Authors
WOOLHOUSE AD GAINSFORD GJ CRUMP DR
Citation
Ad. Woolhouse et al., AN EVALUATION OF HOFMANN AND COPE ELIMINATION ROUTES TO (PLUS-OR-MINUS)-2-N-PROPYLTHIETANE, Journal of heterocyclic chemistry, 30(4), 1993, pp. 873-880
Citations number
31
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of heterocyclic chemistry → ACNP
ISSN journal
0022152X
Volume
30
Issue
4
Year of publication
1993
Pages
873 - 880
Database
ISI
SICI code
0022-152X(1993)30:4<873:AEOHAC>2.0.ZU;2-5
Abstract
A synthetic route to (+/-)-2-n-propylthietane 1 that utilises a silver oxide-induced Hofmann elimination is described together with an evalu ation of the potential of a Cope elimination as an alternative and mor e cost-effective route to 1. Some chemistry of the isomeric intermedia te thiete sulfones 5 and 12 from each of these respective eliminations is presented.