NATURAL PRODUCT CHEMISTRY .159. 2 METHODS FOR THE SYNTHESIS OF 4-AZAACRONYCINE AS A POTENTIAL ANTITUMOR AGENT

Authors
REISCH J DZIEMBA P LAMURA M RAO ARR
Citation
J. Reisch et al., NATURAL PRODUCT CHEMISTRY .159. 2 METHODS FOR THE SYNTHESIS OF 4-AZAACRONYCINE AS A POTENTIAL ANTITUMOR AGENT, Journal of heterocyclic chemistry, 30(4), 1993, pp. 981-983
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of heterocyclic chemistry → ACNP
ISSN journal
0022152X
Volume
30
Issue
4
Year of publication
1993
Pages
981 - 983
Database
ISI
SICI code
0022-152X(1993)30:4<981:NPC.2M>2.0.ZU;2-1
Abstract
Two different methods for the synthesis of 4-azaacronycine (10) have b een described. One route with a fusion reaction between 1,3-dihydroxy- 10-methyl-9(10H)-acridinone (1) and 2-amino-2-methyl-3-butyne in a gla ss ampoule and the other by a reaction of 3-amino-1-methoxy-10-methyl- 9(10H)-acridinone (9) with 2-chloro-2-methyl-3-butyne.