CHIRALITY OF THE 3-HYDROXY-3-METHYLGLUTARIC ACID MOIETY OF FASCICULICACID-A, A CALMODULIN ANTAGONIST ISOLATED FROM NAEMATOLOMA-FASCICULARE

Authors
NOZOE S TAKAHASHI A OHTA T
Citation
S. Nozoe et al., CHIRALITY OF THE 3-HYDROXY-3-METHYLGLUTARIC ACID MOIETY OF FASCICULICACID-A, A CALMODULIN ANTAGONIST ISOLATED FROM NAEMATOLOMA-FASCICULARE, Chemical and Pharmaceutical Bulletin, 41(10), 1993, pp. 1738-1742
Citations number
12
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
41
Issue
10
Year of publication
1993
Pages
1738 - 1742
Database
ISI
SICI code
0009-2363(1993)41:10<1738:COT3AM>2.0.ZU;2-H
Abstract
The chirality of the 3-hydroxy-3-methylglutaric acid (HMGA) moiety of fasciculic acid A (1), a calmodulin antagonist isolated from Naematolo ma fasciculare, was established to be S by comparing the H-1-NMR spect rum of the L-alanylamide of HMGA derived from 1 with those of its dias tereomer and the diastereomeric mixture.