ELECTROCHEMICAL OXIDATION OF ANTITUMOR AGENT, ETOPOSIDE

Authors
OBATA R OHNUMA T
Citation
R. Obata et T. Ohnuma, ELECTROCHEMICAL OXIDATION OF ANTITUMOR AGENT, ETOPOSIDE, Chemical and Pharmaceutical Bulletin, 41(10), 1993, pp. 1846-1847
Citations number
6
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
41
Issue
10
Year of publication
1993
Pages
1846 - 1847
Database
ISI
SICI code
0009-2363(1993)41:10<1846:EOOAAE>2.0.ZU;2-L
Abstract
As part of a search for new potent derivatives, electrochemical oxidat ion of etoposide (1) was carried out under controlled potential (500 m V) to yield 1,2-dehydroetoposide (4), l-1,2,3,4-tetradehydro-4-dehydro xy-podophyllotoxin (5) and 1,2,3,4-tetradehydroetoposide (6). They sho wed no cytotoxicity against B16-melanoma.