Space flight provides a model for the study of healthy individuals und
ergoing unique stresses. This review focuses on how physiological adap
tations to weightlessness may affect nutrient and food requirements in
space. These adaptations include reductions in body water and plasma
volume, which affect the renal and cardiovascular systems and thereby
fluid and electrolyte requirements. Changes in muscle mass and functio
n may affect requirements for energy, protein, and amino acids. Change
s in bone mass lead to increased urinary calcium concentrations, which
may increase the risk of forming renal stones. Space motion sickness
may influence putative changes in gastrointestinal-hepatic function; n
eurosensory alterations may affect smell and taste. Some or all of the
se effects may be ameliorated through the use of specially designed di
etary countermeasures.