INHIBITION OF CHOLINERGIC NEUROTRANSMISSION IN ISOLATED GUINEA-PIG MAIN BRONCHI BY SR-48968

Authors
MARTIN CAE EMONDSALT X ADVENIER C
Citation
Cae. Martin et al., INHIBITION OF CHOLINERGIC NEUROTRANSMISSION IN ISOLATED GUINEA-PIG MAIN BRONCHI BY SR-48968, European journal of pharmacology, 243(3), 1993, pp. 309-312
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European journal of pharmacology → ACNP
ISSN journal
00142999
Volume
243
Issue
3
Year of publication
1993
Pages
309 - 312
Database
ISI
SICI code
0014-2999(1993)243:3<309:IOCNII>2.0.ZU;2-B
Abstract
SR 48968 (10(-6) to 10(-5) M) inhibited the cholinergic response of th e isolated guinea-pig main bronchus to electrical field stimulation. S ince this effect was reversed by naloxone 10(-5) M and since SR 48968 had no effect on the contractile response to exogenous acetylcholine, we conclude that SR 48968 acts at a prejunctional level and that opioi d receptors are involved. This effect was observed at concentrations a pproximately 75000 times higher than those needed for blockade of tach ykinin NK2 receptors.