BRACHMANN-DELANGE SYNDROME WITH NORMAL IQ

The Brachmann-de Lange syndrome is a disorder with a high degree of cl inical variability, generally associated with moderate to severe menta l retardation. To date, 7 previous cases of Brachmann-de Lange syndrom e with normal intelligence (IQ > 70) have been described. We report th e eighth case of Brachmann-de Lange syndrome with normal intelligence. In reviewing the literature, consistent clinical manifestations seen in these 8 patients that are of prognostic value are the absence of si gnificant limb anomalies and birth weight > 2,500 g. (C) 1993 Wiley-Li ss, Inc.