SUPPRESSION OF DELAYED-TYPE HYPERSENSITIVITY (DTH) RESPONSES IN XENOGRAFTS BY PRETREATMENT WITH ULTRAVIOLET (UV)-IRRADIATED HEPATOCYTES

Authors
TANABE S TAURA Y TANAKA M NAKAICHI M NAKAMA S
Citation
S. Tanabe et al., SUPPRESSION OF DELAYED-TYPE HYPERSENSITIVITY (DTH) RESPONSES IN XENOGRAFTS BY PRETREATMENT WITH ULTRAVIOLET (UV)-IRRADIATED HEPATOCYTES, Journal of veterinary medical science, 55(5), 1993, pp. 853-854
Citations number
13
Categorie Soggetti
Veterinary Sciences
Journal title
Journal of veterinary medical science → ACNP
ISSN journal
09167250
Volume
55
Issue
5
Year of publication
1993
Pages
853 - 854
Database
ISI
SICI code
0916-7250(1993)55:5<853:SODH(R>2.0.ZU;2-A
Abstract
F344 Rat hepatocytes (HCs) that had been exposed to ultraviolet (UV) l ight were transplanted into the dorsal subcutaneous tissues of Balb/c mice. Four days after the transplantation, the anti-HC delayed-type hy persensitivity (DTH) response was assessed by determining the response to a direct challenge with non-irradiated HCs. The DTH response in mi ce transplanted with 600 J/m2-UVB-irradiated HCs was suppressed signif icantly compared with that with non-irradiated HCs. Furthermore, the D TH responses evoked by challenge with non-irradiated HCs were similar to those evoked by UV-irradiated HCs.