ESTABLISHMENT AND CHARACTERIZATION OF A FELINE LARGE GRANULAR LYMPHOMA CELL-LINE EXPRESSING INTERLEUKIN-2 RECEPTOR ALPHA-CHAIN

Authors
GOITSUKA R OHNO K MATSUMOTO Y HAYASHI N MOMOI Y OKAMOTO Y WATARI T TSUJIMOTO H HASEGAWA A
Citation
R. Goitsuka et al., ESTABLISHMENT AND CHARACTERIZATION OF A FELINE LARGE GRANULAR LYMPHOMA CELL-LINE EXPRESSING INTERLEUKIN-2 RECEPTOR ALPHA-CHAIN, Journal of veterinary medical science, 55(5), 1993, pp. 863-865
Citations number
9
Categorie Soggetti
Veterinary Sciences
Journal title
Journal of veterinary medical science → ACNP
ISSN journal
09167250
Volume
55
Issue
5
Year of publication
1993
Pages
863 - 865
Database
ISI
SICI code
0916-7250(1993)55:5<863:EACOAF>2.0.ZU;2-V
Abstract
A feline large granular lymphocyte (LGL) cell line was established fro m a cat with an alimentary-form lymphoma. This cell line, designated a s FGL, had many large azurophilic granules in the cytoplasm, which wer e typical to LGL cells. Proviral genome of feline leukemia virus was d etected in the chromosomal DNA of FGL cells, and reverse transcriptase activity was also demonstrated in the culture supernatant. Furthermor e, we found expression of interleukin 2 (IL-2) receptor alpha-chain on the cell surface of FGL and its natural killer activity against human erythroblastic leukemia cell line, K562.