UNDERNUTRITION CHANGES GD3 AND GM2 SYNTHASE ACTIVITIES IN DEVELOPING RAT HYPOTHALAMUS

Authors
TRINDADE VMT SCOTTI L BECKER D GAMALLO JLT PERRY MLS BERNARD EA
Citation
Vmt. Trindade et al., UNDERNUTRITION CHANGES GD3 AND GM2 SYNTHASE ACTIVITIES IN DEVELOPING RAT HYPOTHALAMUS, Journal of nutritional biochemistry, 4(11), 1993, pp. 639-643
Citations number
38
Categorie Soggetti
Nutrition & Dietetics
Journal title
Journal of nutritional biochemistry → ACNP
ISSN journal
09552863
Volume
4
Issue
11
Year of publication
1993
Pages
639 - 643
Database
ISI
SICI code
0955-2863(1993)4:11<639:UCGAGS>2.0.ZU;2-G
Abstract
G(D3) (EC 2.4.99.8) and G(M2) (2.4.1.92) synthases were determined in the hypothalamus of normal (diet: 25% casein) and pre- and postnatally undernourished rats (diet. 8% casein). Both enzymatic activities were statistically higher in the hypothalamus of undernourished rats than in the hypothalamus of control rats on the 21st gestational day. The r esults indicate that undernutrition similarly alters the activity of b oth of these ganglioside biosynthesis enzymes in the rat hypothalamus at the developmental ages studied.