PURPOSE: A retrospective study was performed to determine the success
of percutaneous transthoracic needle biopsy (TNB) as an aid in diagnos
ing focal chest and mediastinal disease in patients with human immunod
eficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS). MA
TERIALS AND METHODS: The study group was composed of 32 patients serop
ositive for HIV; 31 of these patients had known AIDS. The subjects und
erwent chest radiography, computed tomography, and TNB. RESULTS: In 27
of the 32 patients a specific diagnosis was enabled by TNB. Bronchoge
nic carcinoma was diagnosed most frequently, although infectious agent
s were isolated in most patients. CONCLUSION: TNB is a safe and effect
ive procedure for evaluation of focal thoracic disease in this patient
population and provides information that is often unavailable from al
ternative diagnostic procedures.