ISOLATED VAGINAL RECURRENCES OF ENDOMETRIAL CARCINOMA

PURPOSE: The authors undertook this study to evaluate the results of r adiation therapy (RT) for vaginal recurrence in early stage endometria l carcinoma. MATERIALS AND METHODS: Between 1964 and 1987,34 patients with isolated vaginal recurrences of endometrial carcinoma were treate d with RT. The records were reviewed for outcome and prognostic factor s, such as location of tumor recurrence, time to recurrence, size of t umor at recurrence, tumor differentiation, and total radiation dose de livered at RT. RESULTS: With a median follow-up of 48 months, the 5-ye ar actuarial survival and disease-free survival rates were 68% +/- 4 a nd 60% +/- 3, respectively. Results were statistically significant for some prognostic factors, including time to tumor recurrence and total radiation dose delivered at RT to the recurring tumor. CONCLUSION. Lo ng-term survival can be obtained for patients with an isolated vaginal recurrence of endometrial cancer treated with aggressive local-region al radiation therapy.