Continuous positive airway pressure (CPAP) has proven to be a safe, ef
fective treatment for sleep apnea patients. However, many patients dis
play claustrophobic reactions to the CPAP nasal mask and cannot tolera
te this treatment. The current report describes the successful applica
tion of in vivo desensitization with a male apnea patient who initiall
y failed CPAP therapy due to his claustrophobia. Over the course of tr
eatment, the patient became able to tolerate using his CPAP device thr
oughout his nocturnal sleep periods. Moreover, follow-up visits schedu
led 6 months and again at 6 1/2 years after behavioral treatment showe
d that the patient continued to use CPAP on a regular basis. It is con
cluded that in vivo desensitization therapy may be useful in assisting
claustrophobic patients to tolerate nasal CPAP. Results are discussed
in view of the specific features of the case presented, and future ap
plications of this behavioral procedure are encouraged.