The ability of an intravascular ultrasound catheter to give cross-sect
ional images of vessel walls and surrounding tissues, and the behavior
of ultrasound in heterogeneous media, are at the origin of degradatio
n of image quality. Qualitative and quantitative analyses of in vivo s
tudies are then operator-dependent and are limited by artifacts. We in
vestigated these limitations by an in vitro study on plexiglass phanto
ms and segments of fresh arteries. We used a 20 MHz transducer mounted
on the tip of a 4.8 F catheter and an interventional ultrasound syste
m. The ultrasound beam is reflected onto the rotating transducer at 60
0 rotations per minute (RPM), creating 360-degrees real-time images (1
0 images/second). We then observed, analyzed and interpreted the most
specific reasons for image artifacts: geometric distortions, multiple
echoes, the point spread function (PSF) of the imaging system, near-fi
eld effects, ''petal-shaped'' effect, and ultrasound speckle. Various
practical implications have resulted from this study. Only a thorough
knowledge of how to avoid some of the most obvious pitfalls will enabl
e the user to obtain maximum benefits from intravascular ultrasound im
aging, and to appreciate its limitations.