The authors report on three cases of staphylococcal cerebrospinal flui
d (CSF) infection with normal white blood cell count and normal CSF gl
ucose level in repeated lumbar CSF examination. All three children (2
months, 17 months and 4 years old) have been operated for neonatal hyd
rocephalus with setting of a ventriculo-peritoneal shunt one to two mo
nths before. Infection was suspected because of fever without evocativ
e clinical signs. In two cases plasma C reactive protein level was inc
reased, and in all three cases a leucocytosis was present. The diagnos
is was made by bacteriological examination of the ventricular CSF. Bot
h surgical and medical management were required and the bacteriologica
l outcome was favourable. Since neurological sequellae may occur if th
e treatment is delayed such atypical infection needs to be promptly as
sessed.