IMERSLUND-NAJMAN-GRASBECK ANEMIA - A CASE -REPORT

Imerslund-Najman-Grasbeck disease is a rare inherited megaloblastic an aemia secondary to a selective malabsorption of vitamine B12 by ileal enterocytes. The authors report on a 4 year-old tunisian girl who pres ented as visceral infantile leishmaniasis because of huge splenomegaly and major anaemia The diagnosis of Imerslund disease was performed on the basis of the association of typical megaloblastic cells in the ma rrow, permanent proteinuria and favourable outcome under parenteral B1 2 administration. In addition, ther were no folate deficiency, no anti -intrinsic factor antibodies and no intrinsic factor deficiency. The o utcome of the disease is always favourable if parenteral administratio n of vitamine B12 maintained.