DESMOPRESSINE AND WATER-INTOXICATION - A CASE-REPORT

A 4-year-old boy was treated with oxybutinine and desmopressine becaus e of bladder instability associated with secondary enuresis. He was ad mitted with obnubilation, vomiting and experienced two seizure episode s concomitantly with hyponatremia and hypoosmolality. The child healed promptly under water restriction and intravenous administration of so dium chloride. This case report suggests that desmopressine may be res ponsible for severe side-effects. This drug should not be widely used and its indications should be restricted to patients with proven antid iuretic hormone secretion abnormalities.