WHILE the inhibitory effect of metyrapone on the biosynthesis of adren
al corticosteroid hormones is well known, the drug has not been tested
for central actions. The present study is aimed at finding out the di
rect central action of metyrapone, if any, employing feeding behaviour
as a test parameter. Low doses of metyrapone (10-1000 ng) administere
d via an i.c.v. route reduced the food intake in a dose dependent mann
er; the effect was functionally antagonized by concomitant administrat
ion of anti-CRF antisera. The results reveal for the first time, that
metyrapone might be capable of exerting a direct action on the adrenal
cortex.