Escherichia coil cells exposed to heat (48 degrees C), cold (5-15 degr
ees C), oxidative (N-ethylmaleimide), and tetracycline-induced stresse
s secreted as yet unidentified compounds (exometabolites) into the med
ium. These compounds protected E. coil cells against the same or other
stresses. The activity spectra, i.e., the potency of protection again
st different stresses, varied depending on the origination conditions
of the exometabolites.