G. Viola et al., ABSORPTION AND DISTRIBUTION OF ARACHIDONATE IN RATS RECEIVING LYSOPHOSPHOLIPIDS BY ORAL ROUTE, Journal of lipid research, 34(11), 1993, pp. 1843-1852
Absorption and distribution of polyunsaturated fatty acids was investi
gated in rats receiving lysophospholipids per os (30 mg kg-1). Lysopho
sphatidylcholine (lysoPC) increased [H-3]arachidonate absorption and i
ts incorporation into mucosal phosphatidylcholine. Transport of [H-3]a
rachidonate by the phospholipid fraction of lymph lipoproteins and the
level of [H-3]arachidonate in plasma and liver lipids was also increa
sed by lyso PC. Lysophosphatidylserine also increased [H-3]arachidonat
e absorption but channeled the fatty acids into the aminophospholipid
fraction of mucosal phospholipids, thus decreasing its efflux in lymph
lipoproteins. As a consequence, lysophosphatidylserine caused [H-3]ar
achidonate accumulation in mucosa. As similar results were obtained wi
th [C-14]linoleate, the data suggest that the addition of an appropria
te lysophospholipid to the diet may direct absorption and distribution
of polyunsaturated fatty acids.