DOES THE HIV NEF PROTEIN MIMIC THE MHC

Authors
HOBOHM U SANDER C
Citation
U. Hobohm et C. Sander, DOES THE HIV NEF PROTEIN MIMIC THE MHC, FEBS letters, 333(3), 1993, pp. 211-213
Citations number
17
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
333
Issue
3
Year of publication
1993
Pages
211 - 213
Database
ISI
SICI code
0014-5793(1993)333:3<211:DTHNPM>2.0.ZU;2-6
Abstract
The sequence of the HIV Nef protein has no significant homology to oth er proteins in the SwissProt database, and experimental data concernin g its function are sparse and contradictory. Using a novel protein seq uence comparison method, we find similarities between different Nef se quences and the alpha chain of human MHC class I proteins. The possibl e biological implications of this finding are discussed.