PHARMACEUTICAL APPLICATIONS OF A BONDED CYCLODEXTRIN STATIONARY-PHASE

Open tubular columns were coated with Chirasil-Dex, a polysiloxane anc hored permethylated beta-cyclodextrin stationary phase. A number of ch iral separations of pharmaceuticals and agrichemicals are presented to demonstrate the usefulness of this stationary phase in both GC and SF C. Racemates of various amines, amino acids, amino alcohols, carboxyli c acids, coumarines, diols, and imides were resolved. To achieve accep table separation of some enantiomers, a series of derivatives were stu died. In many cases, cyclic derivatives and free acids gave the highes t enantioselectivity.