RELATIONSHIP BETWEEN BLOOD-GROUPS AND TUMOR GRADE, NUMBER, SIZE, STAGE, RECURRENCE AND SURVIVAL IN PATIENTS WITH TRANSITIONAL-CELL CARCINOMA OF THE BLADDER
Mp. Raitanen et Tlj. Tammela, RELATIONSHIP BETWEEN BLOOD-GROUPS AND TUMOR GRADE, NUMBER, SIZE, STAGE, RECURRENCE AND SURVIVAL IN PATIENTS WITH TRANSITIONAL-CELL CARCINOMA OF THE BLADDER, Scandinavian journal of urology and nephrology, 27(3), 1993, pp. 343-347
Blood group was correlated with the tumour grade, number, size, stage
and recurrence rate and with survival in 261 consecutive patients with
bladder cancer analyzed at least five years after diagnosis of the di
sease. The distribution of blood groups did not differ from that in th
e general population. There were no significant differences in the inc
idence of invasion at the time of diagnosis or later, in the number of
the tumours or in the recurrence rate. A tendency for high-grade and
large-sized tumours was observed in the blood groups 0(H) and B. Diffe
rences in mortality were not observed until eight years after diagnosi
s, so that 28% of the patients with blood group A and 40% of those wit
h blood group 0 had died of bladder cancer by ten years after diagnosi
s. Since the differences are small, the clinical significance of blood
groups as a prognostic factor in bladder cancer patients is minimal.
However, there seems to be a need for further research of the signific
ance of genetic background in the natural history of bladder cancer.